Antagonistic Pleiotropy in Human Disease | 私立大學五星教授網

Antagonistic pleiotropy is an evolutionary theory (Gaillard & Lemaitre, 2017) that postulates that certain genes or alleles may differentially impact fitness during the lifespan of an organism (Tuminello & Han, 2011). From: Archives of Oral Biolog

The antagonistic pleiotropy hypothesis was first proposed in a 1952 paper on the evolutionary theory of ageing by Peter Medawar and developed further in a ...

由 J Mitteldorf 著作 · 2019 · 被引用 36 次 — Antagonistic pleiotropy evolves as an evolvability adaptation that protects long term group-level benefits from being lost to short term individual selection.

由 D Wu 著作 · 2022 · 被引用 13 次 — The antagonistic pleiotropy theory of aging proposes that genes enhancing fitness in early life limit the lifespan, but the molecular evidence ...

由 SG Byars 著作 · 2020 · 被引用 64 次 — Pleiotropy is a well-known mode of gene action (Barreiro et al. 2008; Knight et al. 2006) and has been proposed to explain why patterns of ...

由 SN Austad 著作 · 2018 · 被引用 153 次 — Antagonistic pleiotropy, as it applies to aging, hypothesizes that animals possess genes that enhance fitness early in life but diminish it in later life and ...

由 J Mitteldorf 著作 · 2019 · 被引用 36 次 — Antagonistic pleiotropy evolves as an evolvability adaptation that protects long term group-level benefits from being lost to short term ...

由 P Chen 著作 · 2020 · 被引用 49 次 — A nonsynonymous mutation that rises to a high frequency in a population may precipitously drop in frequency at a later time. In addition to its ...

由 SN Austad 著作 · 2018 · 被引用 153 次 — Antagonistic pleiotropy, as it applies to aging, hypothesizes that animals possess genes that enhance fitness early in life but diminish it in ...

Antagonistic pleiotropy evolves as an evolvability adaptation that protects long term group-level benefits from being lost to short term individual selection.